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2.3 Assessment of metE antigen immunogenicity and efficacy using in vivo aerosol MTB challenge studies Following promising results from the MGIA experiments, we then assessed whether the metE antigen, when delivered as a DNA vaccine or as a protein/adjuvant combination, could protect against an aerosol MTB challenge in mice ( Figure 5A )

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509 AS-252424 is a specific and targeted ACSL4 inhibitor that binds directly to the glutamine 464 of ACSL4 to inhibit its enzymatic activity, thereby inhibiting lipid peroxidation and ferroptosis, effectively alleviating ferroptosis-mediated organ damage in mouse models, including I/R-induced kidney injury and acute liver injury

FIGURE 2 2.1 Polyphenols Silymarin, the flavonoid extract from the Silybum marianum (L.) Gaertn

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